MCC950 sodium (CP-456773 sodium

Name	N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide monosodium salt
Synonyms	MCC950 sodium MCC-950 SODIUM CP456773 SODIUM CP-456773 sodium CP-456773 SODIUM CRID3 SODIUM SALT CRID-3 SODIUM SALT CP-456773 sodium salt MCC950 (CP-456773) sodium MCC950 SODIUM SALT (CP-456773) MCC950 sodium (CP-456773 sodium N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide monosodium salt
CAS	256373-96-3

Molecular Formula	C20H23N2NaO5S
Molar Mass	426.46179
Solubility	H₂O: ≥ 30 mg/mL
Appearance	powder
Color	white to beige
Storage Condition	room temp
In vitro study	MCC950 inhibits classical and non-classical NLRP3 activation with IC50 of 7.5 and 8.1 nM in bone marrow-derived macrophages and human monocyte-derived macrophages, respectively. MCC950 specifically inhibits the activation of NLRP3 and does not inhibit AIM2, NLRC4 or NLRP1 These inflammasomes.
In vivo study	MCC950 reduces interleukin-1β (IL-1β) production and reduces the severity of experimental autoimmune encephalomyelitis. In a mouse model of the autoinflammatory disease Cryopyrin-associated cyclic syndrome, MCC950 was able to rescue neonatal death. In indirect in vitro experiments, it was active in samples derived from patients with Veyer's syndrome.

Last Update：2024-01-02 23:10:35

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Product Name: MCC-950 Sodium Salt Request for quotation
CAS: 256373-96-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Product Name: MCC950 (sodium) Visit Supplier Webpage Request for quotation
CAS: 256373-96-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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MCC950 sodium (CP-456773 sodium

MCC950 sodium (CP-456773 sodium Request for Quotation